effect of intranasal sedation using ketamine and midazolam on behavior of 3-6 year-old uncooperative children in dental office: a clinical trial
نویسندگان
چکیده
objectives: the aim of the present study was to compare the effects of intranasal ketamine and midazolam on behavior of 3-6 year-old children during dental treatments. materials and methods: in this randomized cross-over clinical trial, 17 uncooperative children requiring at least two dental treatments were selected and randomly received ketamine (0.5mg/kg) or midazolam (0.2mg/kg) prior to treatment. the other medication was used in the next visit. the children’s behavioral pattern was determined according to the houpt's scale regarding sleep, movement, crying and overall behavior. physiological parameters were also measured at different time intervals. the data were subjected to wilcoxon signed rank test and two-way repeated measures anova. results: the frequency of crying decreased significantly following ketamine administration compared to midazolam (p=0.002); movement of children decreased with fewer incidence of treatment interruption (p=0.001) while their sleepiness increased (p=0.003). despite higher success of sedation with ketamine compared to midazolam, no significant differences were found between the two regarding patients’ overall behavior (p>0.05). the patients had higher heart rate and blood pressure with ketamine; however, no significant difference was found regarding respiratory rate and oxygen saturation (p>0.05). conclusions: ketamine (0.5mg/kg) led to fewer movements, less crying and more sleepiness compared to midazolam (0.2mg/kg). no significant differences were found between the two drugs regarding children’s overall behavior and sedation efficiency. both drugs demonstrated positive efficacy for sedation of children during dental treatments.
منابع مشابه
Effect of Intranasal Sedation Using Ketamine and Midazolam on Behavior of 3–6 Year-Old Uncooperative Children in Dental Office: A Clinical Trial
OBJECTIVES The aim of the present study was to compare the effects of intranasal ketamine and midazolam on behavior of 3-6 year-old children during dental treatments. MATERIALS AND METHODS In this randomized cross-over clinical trial, 17 uncooperative children requiring at least two dental treatments were selected and randomly received ketamine (0.5mg/kg) or midazolam (0.2mg/kg) prior to trea...
متن کاملcomparison of oral and intranasal midazolam/ketamine sedation in 3‒6-year-old uncooperative dental patients
background and aims. there are several known sedative drugs, with midazolam and ketamine being the most com-monly used drugs in children. the aim of this study was to compare the effect of intranasal and oral midazolam plus ket-amine in children with high levels of dental anxiety. materials and methods. a crossover double-blind clinical trial was conducted on 23 uncooperative children aged 3‒6 ...
متن کاملComparison of Oral and Intranasal Midazolam/Ketamine Sedation in 3-6-year-old Uncooperative Dental Patients
Background and aims. There are several known sedative drugs, with midazolam and ketamine being the most commonly used drugs in children. The aim of this study was to compare the effect of intranasal and oral midazolam plus ketamine in children with high levels of dental anxiety. Materials and methods. A crossover double-blind clinical trial was conducted on 23 uncooperative children aged 3-6 (n...
متن کاملEffect of intranasal midazolam with/without inhalation sedation (N2O/O2) in 3‒6-year-old uncooperative dental patients
Introduction: Due to incomplete development of coping skills in children, they usually cannot cope with stressful situations like dental appointments. The present study aims to evaluate the effect of intranasal midazolam with/without inhalation sedation (N2O/O2) in children with high levels of dental anxiety. Materials and Methods: This crossover double-blinded clinical trial was conducted on 1...
متن کاملPhysiologic Effects of Intra-nasal Sedation with Midazolam and Ketamine in 3-6 Years old Uncooperative Children
Objective: Several medications have been used for sedation in children in dentistry and intra-nasal route has been reported to be an efficient way regarding patient cooperation. The aim of the present study was to compare the changes in physiologic parameters following intra-nasal midazolam and ketamine administration. Methods: In this randomized cross-over double-blind trial, 17 uncooperat...
متن کاملphysiologic effects of intra-nasal sedation with midazolam and ketamine in 3-6 years old uncooperative children
objective: several medications have been used for sedation in children in dentistry and intra-nasal route has been reported to be an efficient way regarding patient cooperation. the aim of the present study was to compare the changes in physiologic parameters following intra-nasal midazolam and ketamine administration. methods: in this randomized cross-over double-blind trial, 17 uncooperativ...
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عنوان ژورنال:
journal of dentistry, tehran university of medical sciencesجلد ۱۴، شماره ۱، صفحات ۱-۶
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